In 2019, the University of San Diego and 211 San Diego partnered to apply data science strategies to data collected within the 211/Community Information Exchange San Diego (CIE) information hub, with the goal of understanding factors that could lead to homelessness. This data contains Social Determinants of Health (SDoH) indicators collected by 211 or CIE partners at the time a caller reaches out to access social services. According to the World Health Organization (WHO), SDoH are the conditions in which people are born, grow, live, work, and age. SDoH factors such as housing, nutrition, and utility security are important contributors to health and wellness. Data analytics and research play a critical role in deepening our understanding in this area.